Structure & Function of Chromatin

Working Group of Gerald Brosch

About

The main research focus of the lab lies on elucidating the functional impact of histone/protein arginine methylation on fungal physiology. We are interested in studying to what extent histone modifying activities are involved in fungal pathogenicity as well as to investigate their role in the regulation of secondary metabolite production. The elucidation of PRMT- and HDAC regulated bioactive molecules of Aspergillus is another issue.

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- Chromatin-linked mechanisms of gene expression control
- Isolation and identification of novel targets of PRMTs
- PRMT- and HDAC regulated small bioactive molecules of Aspergillus
- Liquid chromatography (IEX, SEC, HIC, Affinity, RP) on preparative and analytical HPLC systems
- In vivo and in vitro detection of chromatin modifiers (extraction of nuclear proteins, activity assays, autoradiography etc.)
- Expression and purification of recombinant proteins in bacteria and fungi
- Generation of mutant strains of filamentous fungi
- Phenotypical and transcriptional analyses of (mutated) fungal strains
→ Show all publications on PubMed

Projects

Protein methylation in Aspergillus nidulans

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People

Group Leader

Assoz. Prof. Mag. Dr. Gerald Brosch

Medical University of Innsbruck - Division of Molecular Biology
gerald.brosch@i-med.ac.at
+43 512 9003 70211

Group Members

Ingo Bauer, PhD

Postdoc; Structure and function of chromatin: Histone and non-histone methylation in filamentous fungi Studies the impact of chromatin modifiers, in particular of PRMTs, on viability and metabolism of selected fungi. ingo.bauer@i-med.ac.at

Structure & Function of Chromatin

Working Group of Gerald Brosch

WG Brosch